General Information

  • ID:  hor002486
  • Uniprot ID:  NA
  • Protein name:  helodermin
  • Gene name:  NA
  • Organism:  Heloderma suspectum
  • Family:  NA
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  HSDAIFTQQYSKLLAKLALQKYLASILGSRTSPPP
  • Length:  35
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T35 Proline amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor002486_AF2.pdbhor002486_ESM.pdb

Physical Information

Mass: 445111 Formula: C176H284N46O50
Absent amino acids: CEMNVW Common amino acids: L
pI: 10.33 Basic residues: 5
Polar residues: 10 Hydrophobic residues: 13
Hydrophobicity: -13.71 Boman Index: -3347
Half-Life: 3.5 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 100.57
Instability Index: 4993.71 Extinction Coefficient cystines: 2980
Absorbance 280nm: 87.65

Literature

  • PubMed ID:  6439576
  • Title:  Primary Structure of Helodermin, a VIP-secretin-like Peptide Isolated From Gila Monster Venom